Phase 1 And 2 Liver Detoxification Pathways


Inside the liver cells there are sophisticated mechanisms that have evolved over millions of years to break down toxic substances. Every drug, artificial chemical, pesticide and hormone, is broken down (metabolized) by enzyme pathways inside the liver cells. Many of the toxic chemicals that enter the body are fat-soluble, which means they dissolve only in fatty or oily solutions and not in water. This makes them difficult for the body to excrete. Fat soluble chemicals have a high affinity for fat tissues and cell membranes, which are made of fatty substances. In these fatty parts of the body, toxins may be stored for years, being released during times of exercise, stress or fasting. During the release of these toxins, symptoms such as headaches, poor memory, stomach pain, nausea, fatigue, dizziness and palpitations may occur. The body’s primary defense against metabolic poisoning is carried out by the liver. The liver has two mechanisms designed to convert fat-soluble chemicals into water soluble chemicals so that they may then be easily excreted from the body via watery fluids such as bile and urine. Many substances inhibit cytochrome P450. This situation can cause substantial problems as it makes toxins potentially more damaging because they remain in the body longer before detoxification. Many medications including antacids, Antihistamines, NSAID’s, and many more have the potential to block your livers phase 1/ phase 2 detox pathways. Tylenol is the number one cause of acute liver failure in the United States. Blocking these vital pathways can lead to serious health consequences like immune dysfunction and sometimes even cancer. We live in such a toxic world with toxins in our food, water, and air that it is hard to get around these things. Having your pathways open are very important to your everyday health and well-being. As practitioners we get asked all the time what types of cleansing we recommend for individuals looking to do a detox around the beginning of each year. Our simple answer is that you need to do something daily because we live in an environment soaked in xenoestrogens and cancer promoting factors.

Sulphur containing foods and amino acids stimulate phase II detoxification

For efficient phase two detoxification, the liver cells require sulphur-containing amino acids such as taurine and cysteine. The nutrients glycine, glutamine, choline and inositol are also required for efficient phase two detoxification. Eggs and cruciferous vegetables (eg. broccoli, cabbage, Brussels sprouts, cauliflower), raw garlic, onions, leeks and shallots are all good sources of natural sulphur compounds to enhance phase two detoxification. Thus, these foods can be considered to have a cleansing action.

Lectures pertaining to this blog include:

Toxic World by Dr. Jeff Senechal DC CFMP

Cancer Prevention and Nutrition by Dr. Tent DC ND PhD

  1. #1 by Nedrick Hunch on February 24, 2014 - 9:24 pm

    Thank You Doctor Tent. 10 years ago they (the liver specialist.. Not special at all) They said I could sign up for a Liver transplant, wait in line, and die waiting. Dr. Tent had me fixed in just 2 weeks and I am still here. Bless the man. My Liver test have come back perfect ever since and I get blood test no less than twice a year.

    Liked by 1 person

  2. #2 by apostle James Dempsey on February 23, 2016 - 11:08 am

    Coffee enema Max Gerson and liver cleanse epsom salt Hulda Reger Clark! Believe me they both work Got prostate or bladder problems the deep colon coffee enema 3 times a week for a month but may clear up quicker in just a week! Saw Palmeto and1000 mg daily vitamin C. Lugols iodine 20 drops in glass of water can clear up bladder infections sometimes better than anti biotics no prescription or side effects. Same with colloidal silver I make my own with 2 .9999 pure silver rods jumper wires a 9v battery and glass of filtered water. Takes 5 minutes to make you will never have a cold or flu again for more than a few minutes squirt some in your sinuses gargle some and drink the rest repeat every 4 hours. Till gone usually only takes one dose!


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